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KMID : 0613820150250010029
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Journal of Life Science
2015 Volume.25 No. 1 p.29 ~ p.36
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Anti-MRSA Properties of Prodigiosin from Serratia sp. PDGS 120915
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Ji Keun-Ho
Jeong Tae-Hyug
Kim Young-Tae
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Abstract
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Prodigiosin, a member of natural red pigment family, is produced by Serratia marcescens, and characterized by a common pyrrolylpyrromethane skeleton. This pigment has been reported with the effects of anticancer, immunosuppressant, antifungal, and algicidal activities. Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital infections. In this study, anti-MRSA properties of prodigiosin isolated from Serratia sp. PDGS 120915 were investigated. We identified and purified prodigiosin using high performance liquid chromatography (HPLC) and evaluated anti-MRSA activity. Purified prodigiosin inhibited the growth of MRSA. The minimum inhibitory concentrations (MICs) of prodigiosin were determined to 32 μg/ml against the MRSA strains. Fractional inhibitory concentration (FIC) indices of ampicillin and penicillin were indicated synergistic effects of prodigiosin on MRSA.
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KEYWORD
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Anti-MRSA, prodigiosin, red pigment, Serratia
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